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Science.gov is a portal to government databases and research drawing from a wide spectrum of science agencies across disciplines.
National Technical Reports Library
While no longer being updated with new resources, this serves as a useful database for older federally-funded scientific, technical, engineering, and business information across disciplines.
Office of Scientific and Technical Information (OSTI)
Contains a wide array of science and technical information from all research development projects funded by the U.S. Department of Energy.